11/23/2023 0 Comments Nucleo cmp forteMore interestingly, drug pre-treatment significantly reduced MPP +- and glutamate-induced cell death in SH-SY5Y cells and in rat cortical cells. Nucleo CMP Forte ® pre-treatment significantly increased the rate of cell division in SH-SY5Y cells, as well as the synthesis of triglycerides and phospholipids. Cell viability was measured at different times. We used the human dopaminergic cell line SH-SY5Y and a primary culture of rat cortical cells pre-treated with the drug for 24 hours and then exposed to MPP + or glutamate at a range of concentrations. We examined its neuroprotective effects on cell toxicity induced by glutamate excitotoxicity or by 1-methyl-4-phenyl-pyridinium (MPP +), an in vitro cell model of Parkinson’s disease. Its effects on brain pathologies has re-ceived little attention. It has been prescribed for peripheral nervous system disorders, such as lum-bosciatalgia, diabetic or alcoholic polyneuropathy, or trigeminal neuralgia. The authors have the right to conclude separate supplement agreements that relate to non-exclusive work distribution in the form in which it has been published by the journal (for example, to upload the work to the online storage of the journal or publish it as part of a monograph), provided that the reference to the first publication of the work in this journal is included.Nucleo CMP Forte ® is a nucleotide-based drug consisting of cytidinemonophosphate, uridinemonophosphate, uridin-ediphosphate and uridinetriphosphate. The authors reserve the right to authorship of the work and pass the first publication right of this work to the journal under the terms of a Creative Commons CC BY, which allows others to freely distribute the published research with the obligatory reference to the authors of the original work and the first publication of the work in this journal.Ģ. Our journal abides by the Creative Commons CC BY copyright rights and permissions for open access journals.Īuthors, who are published in this journal, agree to the following conditions:ġ. This work is licensed under a Creative Commons Attribution 4.0 International License. This drug considerably reduces the intensity of manifestations of all kinds of neuropathy connected with inferior alveolar nerve damage Thus, after analyzing the dynamics of complaints and objective data for mandibular fractures in the area of the angle, which is accompanied by damage of the inferior alveolar nerve, it was found that using of Nucleo CMP forte accelerates regression of pain syndrome in the course of treatment. In the main group after treatment a significant positive trend for improving the conduction of the inferior alveolar nerve revealed.Ĭonclusions. In the main group disesthesive symptoms at the end of the observation period were missing, and objective symptoms of inferior alveolar nerve dysfunction had a significant regression. There was a slight positive dynamics in the complaints of the patients on disesthesive symptoms in the region of the mandible in the comparison group. The use of Nucleo CMP forte completely eliminates unpleasant subjective symptoms such as burning sensation, allodynia (distorted pain), sensation of tingling, cramp (twitching). In order to achieve the indicated objective, we have performed a surgical interference and further post-surgical treatment of 60 patients with angular mandibular fractures, accompanied by clinical picture of damaging inferior alveolar nerve alveolar nerve. The aim of our study became a comparative description of main indicators of pain syndrome in patients with mandibular fractures, accompanied by damage of inferior alveolar nerve using conventional treatment scheme, supplemented by application of Nucleo CMP forte. Mandibular fractures, inferior alveolar nerve, Nucleo CMP, pain, electrometric test Abstract Pirogov street, 56, Vinnitsa, Ukraine, 21018, Ukraine Vinnitsa National Medical University named after N.I.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |